ISL is an acronym that can contain many meanings which are listed below.
ISL – Inter Switch Link
There may be many popular meanings for ISL with the most popular definition being that of Inter Switch Link
More ISL Definitions
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Found: Inter-Switch Link (ISL) is a Cisco proprietary protocol that maintains VLAN information, as traffic flows between switches and routers. But this came from a Cisco site and I am not sure if it is correct. I am thinking that it has to do with network switch or inter-switch expansion such as in Fibre Channel Topology.